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目的:探讨肺癌患者血清与癌肿块中白介素-8(IL-8)、白介素-18(IL-18)、肿瘤坏死因子(TNFα)、血管细胞粘附因子-1(sVCAM-1)的变化情况。方法:采用Elisa方法检测12例正常对照,17例肺癌患者手术前后IL-8、IL-18、TNFα、sV-CAM-1在血清和癌旁肺组织、癌组织中的含量。结果:肺癌患者手术前后血清中的IL-8、IL-18、TNFα、sVCAM-1含量均比正常对照组增高有显著差异(P值均<0.01)。术后与术前两组比较术后TNFα含量有明显下降(P<0.05),其余3项指标有一定下降但无显著差异。癌肿块中IL-8、IL-18、TNFα、sVCAM-1含量比癌旁组织中的含量4项指标均显著增高(P<0.01,P<0.05)。结论:测定血清中的IL-8、IL-18、TNFα、sVCAM-1对肺癌的诊断及判断预后,鉴别良、恶性肿瘤有重要临床意义。
Objective: To investigate the changes of interleukin-8, interleukin-18, tumor necrosis factor (TNF-α) and vascular cell adhesion molecule-1 (sVCAM-1) in serum and cancer mass in patients with lung cancer . Methods: Elisa method was used to detect the levels of IL-8, IL-18, TNFα and sV-CAM-1 in serum and paracancer lung tissues and cancer tissues of 12 normal controls and 17 lung cancer patients before and after operation. Results: The levels of IL-8, IL-18, TNFα and sVCAM-1 in lung cancer patients before and after surgery were significantly higher than those in normal controls (all P <0.01). Postoperative and preoperative TNFα levels were significantly decreased (P <0.05), the remaining three indicators have a certain decline but no significant difference. The contents of IL-8, IL-18, TNFα and sVCAM-1 in cancer mass were significantly higher than those in para-cancerous tissue (P <0.01, P <0.05). Conclusion: The determination of serum IL-8, IL-18, TNFα, sVCAM-1 of lung cancer diagnosis and prognosis, the identification of benign and malignant tumors have important clinical significance.