论文部分内容阅读
目的 观察胎脑提取液对衰老小鼠海马神经元酸性磷酸酶 (ACP)和琥珀酸脱氢酶 (SDH)活性的影响 ,探讨胎脑提取液的抗衰老作用。方法 选用健康昆明种小白鼠 30只 ,随机分为 3组 ;采用D -半乳糖制备亚急性衰老模型 ;酶组织化学方法结合显微图像分析 ,观察各组小鼠海马神经元ACP和SDH的活性。结果 衰老模型组与正常对照组相比 ,小鼠海马神经元ACP活性明显升高 ,SDH活性明显降低 ;给药组与衰老模型组相比 ,小鼠海马神经元ACP活性明显降低 ,SDH活性明显升高。结论 胎脑提取液可以延缓海马神经元的衰老进程 ,具有一定的抗衰老作用。
Objective To observe the effects of fetal brain extract on the activity of acid phosphatase (ACP) and succinate dehydrogenase (SDH) in hippocampal neurons of senile mice and explore the anti-aging effects of fetal brain extract. Methods Thirty healthy Kunming mice were randomly divided into three groups. Subacute aging model was induced by D - galactose. The activity of ACP and SDH in hippocampal neurons of mice in each group were observed by enzyme histochemistry and microscopic image analysis . Results Compared with the normal control group, the activity of ACP in hippocampal neurons and the activity of SDH in hippocampus of mice in aging model group were significantly lower than those in normal control group. Compared with the model group, the activity of ACP in hippocampal neurons decreased significantly Rise. Conclusion Fetal brain extract can delay the process of aging of hippocampal neurons and have some anti-aging effects.