前列腺特异性抗原的纵向变化越来越多地用于组织活检结果的一种参考。PSA以0.75 ng/mL/年的速率上升即可认为从良性前列腺增生转变为前列腺癌。然而,这个阈值对于总PSA不高的年轻人来说或许太高。在这项研究中,以年龄≤60岁,且可计算PSA速率的6 844位男性作为入选对象,其中有34 Longitudinal changes in prostate-specific antigen are increasingly being used as a reference for biopsy results. Prolonged conversion of benign prostatic hyperplasia to prostate cancer is seen when PSA is increased at a rate of 0.75 ng / mL / year. However, this threshold may be too high for young people with low total PSA. In this study, 6 844 men aged <60 years with a PSA-calculated rate were enrolled, of whom 34