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目的:观察达宁配合氯硝西泮治疗中重度癌痛的疗效。方法:中度癌痛患者应用达宁1片,tid或qid口服,睡前加服氯硝西泮1～2mg;重度癌痛患者应用达宁2片,tid口服,睡前肌注氯硝西沣1mg。结果:中度癌痛治疗有效率为100%,显效率23%;重度癌痛治疗有效率为87.5%,显效率28%。经统计学处理,两者有效率有显著性差异(P<0.05);显效率无显著意义(P>0.05)。中重度癌痛治疗总有效率95%。结论:达宁配合氯硝西泮治疗癌痛疗效确切,副作用少,可使二阶梯止痛时间延长。
Objective: To observe the efficacy of Daning and clonazepam in the treatment of moderate to severe cancer pain. METHODS: One patient with moderate cancer pain was treated with Daning, tid or qid orally, plus clonazepam 1 to 2 mg before bedtime; 2 patients with severe cancer pain using Daning, oral tid, and intramuscular injection of clonazepam before bedtime沣 1mg. Results: The effective rate of moderate cancer pain was 100%, and the effective rate was 23%. The effective rate of severe cancer pain was 87.5% and the significant rate was 28%. After statistical analysis, there was a significant difference in the efficiency between the two (P<0.05); the significant efficiency was not significant (P>0.05). The total effective rate of moderate and severe cancer pain is 95%. Conclusion: Daning combined with clonazepam has a definite curative effect on cancer pain with less side effects, which can prolong the time for two-step analgesia.