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目的探讨2型糖尿病(T2DM)患者腰身指数(WHtR)与胰岛功能的相关性。方法 T2DM患者179例,以WHtR0.5为切点分为非肥胖组和肥胖组,比较两组间的稳态模型胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-IS)、胰岛素曲线下面积(AUCINS)和血糖曲线下面积(AUCPG),并行Pearson相关分析和多元逐步回归分析。结果肥胖组较非肥胖组ln(AUCINS)、ln(HOMA-IR)和ln(HOMA-IS)升高,差别具有统计学意义(P<0.05);WHtR与ln(AUCINS)、ln(HOMA-IR)和ln(HOMA-IS)呈正相关,r值分别为0.392、0.359、0.414,P<0.01;多元逐步回归分析显示,ln(HOMA-IS)是WHtR的独立影响因素(P<0.01)。结论 WHtR是胰岛素抵抗和高胰岛素血症良好的预测因子。
Objective To investigate the relationship between the islet index (WHtR) and islet function in patients with type 2 diabetes mellitus (T2DM). Methods 179 patients with T2DM were divided into non-obese group and obesity group with WHtR0.5 as the cut-off point. HOMA-IR, HOMA-IS, insulin curve Area under the curve (AUCINS) and area under the curve of blood glucose (AUCPG), parallel Pearson correlation analysis and multiple stepwise regression analysis. Results The levels of ln (AUCINS), ln (HOMA-IR) and ln (HOMA-IS) in obesity group were significantly higher than those in non-obesity group (P <0.05) IR) and ln (HOMA-IS), r values were 0.392,0.359,0.414, P <0.01. Multiple stepwise regression analysis showed that ln (HOMA-IS) was an independent factor of WHtR (P <0.01). Conclusions WHtR is a good predictor of insulin resistance and hyperinsulinemia.