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1978年Naftifine首先由Berney等合成,后来Georgopoulus等发现具有广谱抗真菌活性,特别对皮肤真菌的活性较好,最小抑菌浓度(MIC)为0.01～0.2mg/L。1985年Naftifine首批在西德、奥地利、马来西亚和新加坡等国上市,其商品名为Exoderil。1989年我们用Naftifine进行了体外试验和动物试验,其结果表明Naftifine对皮肤真菌的抗菌作用,比克霉唑和咪康唑好,特别对临床分离72株红色毛癣菌和24株羊毛状小孢子菌效果较好,MIC_(90)较低。1％Naftifine霜剂和溶液对豚鼠皮肤真菌病的疗效,比1％克霉唑软膏好,并且达到或超过2％达克宁霜和3％克霉唑软膏效果,证明Naftifine是一种较好的新型抗真菌药。
In 1978, Naftifine was firstly synthesized by Berney et al. Later, Georgopoulus et al. Found broad-spectrum antifungal activity, especially for dermatophytes, with a minimum inhibitory concentration (MIC) of 0.01-0.2 mg / L. Naftifine was first listed in 1985 in countries such as West Germany, Austria, Malaysia and Singapore under the trade name Exoderil. In 1989 we used Naftifine in vitro and animal experiments, the results show that the antibacterial effect of Naftifine on skin fungi, clotrimazole and miconazole better, in particular, the clinical isolation of 72 Trichophyton rubrum and 24 small fleece Spore bacteria better, MIC_ (90) lower. The efficacy of 1% Naftifine creams and solutions on guinea pig dermatophytosis was better than 1% clotrimazole ointment and at or above 2% cream and 3% clotrimazole ointment proved Naftifine to be a good new Antifungal.