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目的探讨以血液系统疾病为惟一表现的免疫异常患者的临床特点。方法回顾性分析23例以血液系统疾病为惟一表现的免疫异常初诊患者的临床资料。结果血液学异常多种多样,其中以免疫性血小板减少性紫癜8例,自身免疫性溶血性贫血3例和纯红细胞再生障碍性贫血3例较多见;其次为慢性病性贫血2例、白细胞和血小板减少症2例。23例患者抗核抗体均为阳性,抗双链DNA阳性5例,抗Sm抗体阳性3例,ENA?nRNP抗体阳性7例。结论血液疾病的患者应完善免疫方面相关检查,避免误诊。
Objective To investigate the clinical features of patients with abnormal immune system characterized by hematologic diseases. Methods The clinical data of 23 newly diagnosed patients with immune abnormalities whose manifestations were hematological diseases were retrospectively analyzed. Results Hematological abnormalities varied, including immune thrombocytopenic purpura in 8 cases, 3 cases of autoimmune hemolytic anemia and pure red cell aplasia in 3 cases more common; followed by chronic anemia in 2 cases, white blood cells and Thrombocytopenia in 2 cases. 23 patients were positive for antinuclear antibody, 5 were anti-double-stranded DNA positive, 3 were anti-Sm antibody and 7 were ENA? NRNP antibody. Conclusion Patients with blood diseases should improve the relevant immunological tests to avoid misdiagnosis.