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目的:探讨围绝经期子宫肌瘤保守治疗的远期结局。方法:随机将80例具有适应症,同时愿意接受保守治疗的围绝经期子宫肌瘤患者分成对照组和实验组各40例,对照组患者采用期待疗法,实验组患者采用米非司酮口服治疗;对全部患者进行为期3年的随访,对两组患者的治疗远期结局进行观察分析。结果:随访第三年,两组患者的肌瘤体积、月经量、肌瘤内血流信号、闭经率等指标变化情况比较差异无统计学意义(P>0.05)。结论:临床中在对围绝经期子宫肌瘤患者进行治疗时,采用米非司酮进行保守治疗能取得和期待疗法相近的远期疗效。
Objective: To investigate the long-term outcome of conservative treatment of uterine fibroids in menopause. Methods: Totally 80 cases of perimenopausal uterine fibroids with conservative indications and conservative treatment were randomly divided into control group and experimental group (40 cases each). Patients in control group were treated with expectant therapy. Patients in experimental group were treated with oral mifepristone ; All patients were followed up for 3 years to observe the long-term outcome of the two groups of patients. Results: In the third year of follow-up, there was no significant difference in the changes of fibroids volume, menstrual flow, fibroids blood flow signals and amenorrhea rate between the two groups (P> 0.05). Conclusion: In clinical treatment of perimenopausal uterine fibroids, conservative treatment with mifepristone can achieve long-term efficacy similar to expectant therapy.