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应用组织化学、免疫组织化学、电子显微镜及形态测量等方法对二乙基亚硝胺（ＤＥＮ）诱发大鼠肝肿瘤过程中肥大细胞（ＭＣ）对肝细胞生化代谢、细胞核及核仁组成区（ＮＯＲ）的影响等进行了研究。结果显示肝细胞葡萄糖６磷酸酶（Ｇ－６－Ｐａｓｅ）和α－抗胰蛋白酶（α－ＡＴ）在ＭＣ最多与最少组之间的分布无明显差异，而嗜银蛋白颗粒（ＡｇＮＯＲ）计数和纤维中心数密度及核仁面积之比则自第十四周起显示出分布的个体差异，它们在ＭＣ最多组明显低于ＭＣ最少组、本文并对该种差异的意义进行了简要讨论。
Histochemical, immunohistochemical, electron microscopy, and morphometric measurements of hepatocyte biochemical metabolism, nucleus, and nucleolar composition of mast cells (MC) during diethylnitrosamine (DEN)-induced liver tumors in rats The effects of NOR) were studied. The results showed that there was no significant difference in the distribution of hepatocyte glucose-6-phosphatase (G-6-Pase) and α-antitrypsin (α-AT) between the MC group and the minimal group, while AgNOR counts and The fiber center number density and nucleolar area ratio showed individual differences in distribution since the fourteenth four-year period. They were significantly lower in the MC group than in the MC group, and the significance of this difference was briefly discussed.