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目的 :考察联合应用米索前列醇及缩宫素在产后出血中的预防效果。方法 :选择2014年5月-2015年12月本院分娩60例产妇作为研究对象,随机分为两组(n=30)。对照组单用缩宫素预防产后出血,观察组在对照组的基础上联合米索前列醇治疗,对两组产妇产后2、24h出血量和不良反应进行比较。结果:观察组产妇产后2h阴道出血量为(124.8±19.4)ml、24h阴道出血为(218.4±25.1)ml,对照组产后出血量产妇产后2h、24h阴道出血量分别为(201.3±24.3)ml、(319.8±36.4)ml,差异具有统计学意义(t2h=9.23,p=0.018;t24h=10.98,P=0.014);两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论 :米索前列醇联合缩宫素用于产后出血预防,止血效果好,安全性较高,值得推广使用。
Objective: To investigate the preventive effect of combination of misoprostol and oxytocin in postpartum hemorrhage. Methods: From May 2014 to December 2015, 60 pregnant women delivered in our hospital were selected as study subjects and randomly divided into two groups (n = 30). In the control group, oxytocin alone was used to prevent postpartum hemorrhage. The observation group was treated with misoprostol on the basis of the control group, and the amount of bleeding and adverse reactions at postnatal days were compared between the two groups. Results: The amount of vaginal bleeding in the observation group was (124.8 ± 19.4) ml at 2 hours postpartum and (218.4 ± 25.1) ml at 24 hours postpartum in the observation group. The amount of vaginal bleeding in the control group was (201.3 ± 24.3) ), (319.8 ± 36.4) ml, the difference was statistically significant (t2h = 9.23, p = 0.018; t24h = 10.98, P = 0.014). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion: Misoprostol combined with oxytocin for postpartum hemorrhage prevention, hemostatic effect is good, safe, it is worth promoting the use.