致病性大肠杆菌(EPEC)是婴儿室发生新生儿流行性腹泻的最常见病原之一。作者观察了某婴儿室的新生儿流行性腹泻62例,多在出生后2～7天内发病,40例经用抗生素治疗后迅速治愈。重症22例大便培养18例为EPEC O_(128)B_(12)生长。通过观察发现,致病性大肠杆菌的O_(128)B_(12)型引起的腹泻病情较重,病死率较高,应引起重视。该型细菌感染主要引起坏死性小肠结肠炎,病情的轻重不仅与感染有关,还与出生体重、胎龄、Apgar评分、低氧血症等综合性因素有关。作 Pathogenic Escherichia coli (EPEC) is one of the most common causes of neonatal diarrhea in infants. The authors observed 62 infants with neonatal diarrhea in a baby room, most of whom developed morbidity within 2 to 7 days after birth, and 40 were cured promptly after treatment with antibiotics. Eighteen patients with severe stool were cultured for EPEC O_ (128) B_ (12) growth. Through observation, it was found that pathogenic Escherichia coli O_ (128) B_ (12) type of diarrhea caused by severe illness, high mortality, should be taken seriously. This type of bacterial infection mainly causes necrotizing enterocolitis, the severity of the disease is not only related to infection, but also with the birth weight, gestational age, Apgar score, hypoxemia and other comprehensive factors. Make