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目的通过回顾性分析新疆医科大学附属肿瘤医院2010-2013年间收治的宫颈癌患者病例资料,探讨新疆宫颈癌的疾病特点及维吾尔族、汉族宫颈癌的人乳头瘤病毒(HPV)感染特点,了解新疆地区宫颈癌发病状况,为诊治及预防提供基本资料依据。方法收集和整理2010年1月-2013年12月4年间新疆医科大学附属肿瘤医院收治的3 753例宫颈癌临床资料,进行整体分析及维吾尔族、汉族对比分析。结果 2010年1月-2013年12月新疆医科大学附属肿瘤医院收治的宫颈癌患者人数2013年增长最快,定基比增长8.8%,环比增长8.7%;共计3 753例,其中维吾尔族1 972例、占52.5%,汉族1 468例、占39.1%,其他民族313例、占8.3%;主要发病年龄在36~60岁,中位年龄48岁,其中汉族47岁、维吾尔族50岁,二者发病年龄差异有统计学意义(χ~2=103.12,P<0.05);HPV检测率84.4%,HPV阳性率88.0%,其中维吾尔族达90.0%、汉族83.0%,维吾尔族患者HPV阳性率显著高于汉族,差异有统计学意义(χ~2=19.092,P<0.05),维吾尔族患者年龄段主要在20~59岁,阳性者占95.4%,较汉族HPV感染高峰年龄推迟10年、二者差异有统计学意义(χ~2=110.311,P<0.05)。结论新疆医科大学附属肿瘤医院收治的宫颈癌患者分布有明显的民族差异性、以维吾尔族居多,与汉族相比在发病年龄及HPV感染高峰年龄上均不同,应加强对适龄妇女宫颈病变的筛查和管理,才能更好地预防宫颈癌的发生。
Objective To investigate the characteristics of cervical cancer in Xinjiang and the human papillomavirus (HPV) infection in Uygur and Han nationality by retrospectively analyzing the data of patients with cervical cancer admitted from 2010 to 2013 at Cancer Hospital Affiliated to Xinjiang Uygur Medical University. Regional cervical cancer incidence, provide basic information for diagnosis and treatment. Methods The clinical data of 3 753 cases of cervical cancer admitted to Cancer Hospital Affiliated to Xinjiang Medical University from January 2010 to December 2013 were collected and collated, and the overall analysis and the comparative analysis of Uighur and Han nationality were collected. Results The number of cervical cancer patients admitted to Cancer Hospital Affiliated to Xinjiang Medical University from January 2010 to December 2013 increased the fastest in 2013, with the base rate increasing by 8.8% and increasing by 8.7% compared with the previous period; a total of 3 753 cases were included, among which 1 972 cases were Uygur , Accounting for 52.5%, Han 1 468, accounting for 39.1%, 313 other ethnic groups, accounting for 8.3%; the main age at onset of 36 to 60 years old, the median age of 48 years, of which Han 47 years old, Uighur 50 years old, both The incidence of HPV was 84.4%, the positive rate of HPV was 88.0%, of which 90.0% were Uygur and 83.0% Han, and the positive rate of HPV was significantly higher in Uigur patients (χ ~ 2 = 103.12, P <0.05) In Han nationality, the difference was statistically significant (χ ~ 2 = 19.092, P <0.05). The age group of Uyghur patients was mainly from 20 to 59 years old, accounting for 95.4%, which was 10 years later than the peak age of Han nationality HPV infection The difference was statistically significant (χ ~ 2 = 110.311, P <0.05). Conclusion There are obvious ethnic differences in the distribution of cervical cancer patients at the Tumor Hospital Affiliated to Xinjiang Medical University. Most Uighur ethnic groups are different from the Han nationality in age of onset and peak age of HPV infection. Screening of cervical lesions in women of the same age should be strengthened Check and management, in order to better prevent the occurrence of cervical cancer.