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选择３组心内直视手术的病人，分别静滴配制４小时以内（对照组，ｎ＝９）、１２～１４小时（ｎ＝９）、２２～２４小时（ｎ＝９）硝普纳溶液，测量各组血液中硫氰酸盐、氰化物含量并记录硝普钠用量，同时对配制后２４小时硝普纳溶液的降解度和氰化物含量进行测定。结果表明：按常规配制、使用硝普钠溶液２４小时以内是稳定的，临床上延长硝普钠溶液使用时限至２４小时是可行的。
Patients in the 3 groups undergoing open heart surgery were treated with intravenous drip infusion for 4 hours (n = 9), 12-14 hours (n = 9), 22-24 hours (n = 9) The contents of thiocyanate and cyanide in the blood of each group were measured and the dosage of sodium nitroprusside was recorded. At the same time, the degradation and cyanide content of the nitroprusside solution were determined 24 hours after preparation. The results showed that: according to conventional preparation, the use of sodium nitroprusside solution within 24 hours is stable, prolonged use of sodium nitroprusside solution to 24 hours is feasible.