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作者报导101名慢粒急变病例,其中7例(6.9％)发生脑膜白血病。在99例死亡病例中,12例曾获完全缓解,其中数存活期为12月(3～28月),不全完缓解者的中数存活期只有2.5月(1～14月)。12例完全缓解者中5例(42％)发生脑膜白血病,而在不完全缓解者中只2例(2.3％)发生脑膜白血病。主要的神经系统体征为颅神经麻痹和视乳头水肿,所有患者脑脊液的白细胞均增加,并出现原始粒细胞。鞘内注射氨甲喋呤对脑膜白血病非常有效,所有患者脑脊液的白细胞恢复正常,5例的神经系统症状和体征完全
The authors reported 101 patients with acute myasthenia gravis, of which 7 (6.9%) developed leukemia. Of the 99 deaths, 12 had a complete remission, with a median survival of 12 months (March to 28) and a median survival of 2.5 months (January to 14 months) for those with incomplete remission. Mening leukemia occurred in 5 (42%) of the 12 patients with complete remission and in 2 (2.3%) of patients with incomplete remission. The main neurological signs were cranial nerve palsy and papilledema, and all patients had an increase in white blood cells in cerebrospinal fluid and the presence of primitive granulocytes. Intrathecal methotrexate was very effective for meningococcal leukemia, all patients had normal CSF white blood cells returned to normal, and 5 had complete neurological signs and symptoms