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静脉给予β-阻滞剂后肾血流量及肾小球滤过率降低10～20%,文献已有报告。但长期口服给药对肾功能影响则了解甚少。本文介绍8位正常人受试者,男7,女1,年龄20～30岁。心得安剂量为每日80、160、240和320mg,分次口服,连续数周。其中3人每日服心得安320mg 共1月。所有对象于服药前和停药后立即/以及在1、2月后重复测定肾功能,包括肌酐廓清
Intravenous β-blocker renal blood flow and glomerular filtration rate decreased by 10 to 20%, the literature has been reported. However, long-term oral administration of renal function is poorly understood. This article describes eight normal subjects, male 7, female 1, aged 20 to 30 years. Propranolol daily doses of 80,160,240 and 320mg, graded orally for several weeks. Three of them were served with 320mg daily in January. All subjects were tested for renal function immediately before and after discontinuation and after 1 and 2 months, including creatinine clearance