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克拉维酸 (ｃｌａｖｕｌａｎｉｃａｃｉｄ)为抗生素类药物。本文介绍血浆经乙腈脱去蛋白 ,用二氯甲烷抽提除去有机溶剂后用截流混合技术测定人血浆中克拉维酸的方法。克拉维酸和咪唑间的反应动力学特征图是用在 312ｎｍ处测量咪唑衍生物的吸光度来测定 ,反应速率与克拉维酸的浓
Clavulanic acid is an antibiotic. This article describes the method for the determination of clavulanic acid in human plasma by the clonal mixing technique after the plasma is stripped of the protein by acetonitrile and the organic solvent is extracted with dichloromethane. The kinetic profile of the reaction between clavulanic acid and imidazole was determined by measuring the absorbance of the imidazole derivative at 312 nm with a reaction rate comparable to that of clavulanic acid