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自1970年Linfoot等最先报告以来,人们一直设想脑脊液(CSF)中垂体前叶激素浓度的异常增高,标志着分泌该种激素的蝶鞍垂体肿瘤的扩展。而1979年Jordan等证实:催乳素不符合上述设想,CSF中的催乳素水平的实际增高虽与催乳素肿瘤有关,但不能证实蝶鞍肿瘤的扩展。Schroeder等所论述的一例这类病人也提到了这一点。作者们都指出,孕妇CSF中催乳素水平升高,却未见垂体异常。
Since Linfoot et al. first reported in 1970, it has been assumed that the abnormal increase of the anterior pituitary hormone concentration in cerebrospinal fluid (CSF) marks the expansion of sella pituitary tumors that secrete this hormone. In 1979, Jordan et al. confirmed that prolactin does not meet the above assumptions. Although the actual increase in prolactin levels in CSF is related to prolactin tumors, it cannot confirm the expansion of sella tumors. An example of such patients discussed by Schroeder et al. also mentions this point. The authors all pointed out that elevated prolactin levels in pregnant women have no abnormal pituitary glands.