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目的:探讨Ⅱ型糖尿病合并急性脑梗塞与血管内皮素(ET)、胰岛素(INS)及胰高血糖素(GC)水平的关系,以阐明其在脑卒中发生发展过程中的临床意义。方法:采用RIA对36例本病患者进行急性期与恢复期ET、INS及GC含量的测定,并与正常对照组作比较。结果:急性期ET(96.89±23.61ng/L)、INS(24.42±9.84mIU/L)、GC(227.52±71.24ng/L)显著高于恢复期(依次为65.16±12.57ng/L、15.52±5.66mIU/L、178.26±52.76ng/L)及正常对照组(p<0.05～0.001)。结论:本病患者存在ET、INS及GC明显分泌异常,说明其参与了糖尿病脑卒中的病理生理及发生发展过程,动态RIA其血中含量,对判断病情程度、疗效、转归及预后评估具有重要的临床意义。
Objective: To investigate the relationship between type 2 diabetes complicated with acute cerebral infarction and the levels of endothelin (ET), insulin (INS) and glucagon (GC) in order to clarify its clinical significance in the development of stroke. Methods: The contents of ET, INS and GC in acute and convalescent phase of 36 patients with RIA were measured by RIA, and compared with the normal control group. Results: The acute phase ET (96.89 ± 23.61ng / L), INS (24.42 ± 9.84mIU / L) and GC (227.52 ± 71.24ng / L) were significantly higher than those of the recovery stage (65.16 ± 12.57ng / L, 15.52 ± 5.66mIU / L, 178.26 ± 52.76ng / L) and normal control group (p <0.05 ~ 0.001). Conclusion: The patients with abnormal secretion of ET, INS and GC, indicating that they participate in the pathophysiology of diabetes stroke and the occurrence and development of dynamic RIA in the blood, to determine the degree of disease, efficacy, prognosis and prognosis have Important clinical significance.