白介素-1受体相关激酶(the interleukin-1 receptor associated kinases,IRAK)是一类细胞内激酶,在Toll样受体及白介素-1受体介导的信号通路中发挥重要作用,对炎症反应起正向或负向调节作用。近年来的研究表明IRAK参与了脑缺血、脑出血、癫痫、阿尔茨海默病等神经系统疾病的发生发展。本文就IRAK与神经系统疾病的关系研究进展加以综述,有助于研究神经系统疾病的发病机制及寻找新的治疗方向。 The interleukin-1 receptor associated kinases (IRAKs) are a class of intracellular kinases that play an important role in the Toll-like receptor and interleukin-1 receptor-mediated signaling pathways and play an important role in the inflammatory response Positive or negative regulation. Recent studies have shown that IRAK is involved in the development of neurological diseases such as cerebral ischemia, cerebral hemorrhage, epilepsy and Alzheimer’s disease. This review summarizes the research progress on the relationship between IRAK and nervous system diseases, which helps to study the pathogenesis of neurological diseases and find new treatment directions.