【摘 要】
：
目的:研究氧化苦参碱微球(OMAT-PBCA-NP)冻干针剂的动物器官靶向性。方法:采用高效液相色谱法测定给药大鼠各主要脏器的氧化苦参碱含量。色谱条件:Kromasil C18柱(4.60 mm×2
【机 构】
：
广州中医药大学,广州医学院附属肿瘤医院,
论文部分内容阅读
目的:研究氧化苦参碱微球(OMAT-PBCA-NP)冻干针剂的动物器官靶向性。方法:采用高效液相色谱法测定给药大鼠各主要脏器的氧化苦参碱含量。色谱条件:Kromasil C18柱(4.60 mm×250 mm,5μm),流动相甲醇-水-三乙胺(50∶50∶0.02),柱温20℃,检测波长210 nm,流速1 mL.min-1,进样量为10μL。结果:氧化苦参碱在50～400 mg.L-1线性关系良好(r=0.999 0),在30 min,1,4,8 h等时间点中,氧化苦参碱在肝内的含量最高,与其他脏器含量有极显著性差异(P<0.01)。结论OMAT-PBCA-NP具有良好的肝脏靶向性。
OBJECTIVE: To study the animal organ targeting of oxymatrine microspheres (OMAT-PBCA-NP) freeze-dried injection. Methods: The contents of oxymatrine in the main organs of rats were determined by high performance liquid chromatography. Chromatographic conditions: Kromasil C18 column (4.60 mm × 250 mm, 5 μm), mobile phase methanol-water-triethylamine (50:50:0.02), column temperature 20 ℃, detection wavelength 210 nm, , The injection volume of 10μL. Results: Oxymatrine showed a good linearity (r = 0.999 0) at 50-400 mg · L -1, and the highest content of oxymatrine in the liver at 30 min, 1, 4, 8 h (P <0.01), which was significantly different from other organs (P <0.01). Conclusion OMAT-PBCA-NP has good liver targeting.
其他文献
A pot experiment has been carried out under controlled conditions to study the possibility of applying the technique of in vivo staining for acid phosphatase ac
辽宁岫岩软玉砂矿 (又称河磨玉矿 )是原生软玉矿的次生砂矿床。其玉石质地细腻 ,光泽滋润。作为装饰文化的宝玉石资源 ,越来越受到人们的青睐。岫岩软玉砂矿的发现和深入研究
近几十年分析资料对比表明,农田排水对塔里木河干流水质盐化的影响不断加重.在塔里木河干流,农田排水资源化利用有如下几个有利条件:(1)农田排水有一定数量且渠网的延伸和改
目的:观察不同治法方药对2型糖尿病胰岛素抵抗(IR)大鼠细胞因子的影响。方法:以高脂饲料喂养加小剂量链脲佐菌素(STZ)ip的方法建立2型糖尿病IR大鼠模型。给予不同治法的方药
目的 探讨DSA对老年性颈内动脉重度狭窄或闭塞患者侧支循环的诊断价值.方法 广西右江民族医学院附属医院神经内科自2008年8月至2010年7月收治一侧颈内动脉重度狭窄或闭塞的缺
目的 探讨32p-磷酸铬-聚-L-乳酸(32P-CP-PLLA)粒子瘤体间质给药治疗BALB/c裸鼠荷人胰腺癌( BxPc-3)移植瘤的药效学及全身不良反应.方法 24只荷瘤裸鼠,随机分为4组:空白对照组
Chinese lake status database has provided systematic geological records of much higher lake level and fresher water than today at the LGM from western China. Th
After studying the characteristics and special texture of the fluidogenous tectonics,mineral assemblage in the cemented vein between breccia and their special d
IF-like proteins have been obtained from suspension cells of Nicotiana tabacum by selective extraction. Western blot analysis shows that the major components of
目的:比较微创经皮输尿管镜(MPCNL)与逆行输尿管镜(URL)治疗嵌顿性输尿管上段结石的疗效。方法:回顾分析92例临床资料,比较两种方法的碎石成功率、手术时间、术后恢复时间、