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迄今人们都认为在小鼠激活的巨噬细胞是宿主抵抗原发癌或转移性癌的重要防御力量。此外,早在1983年 Kleinerman 等已证明,人类的单核细胞与肺泡巨噬细胞,不论是否被激活,对肿瘤细胞都具有细胞毒作用。现已知激活的单核-巨噬细胞可产生各种单核细胞因子(monokines),诸如白细胞介素1(IL-1)和肿瘤坏死因子(TNF)。已证明这些物质与抗肿瘤的免疫反应有关。肺部的恶性肿瘤常致胸腔积聚恶性渗出液。因此,作者试图了解胸腔渗出液中癌细胞
To date, it has been assumed that mouse-activated macrophages are important defense forces for host defense against primary or metastatic cancer. In addition, as early as 1983 Kleinerman et al. demonstrated that human monocytes and alveolar macrophages, whether activated or not, have cytotoxic effects on tumor cells. It is now known that activated monocytes-macrophages can produce various monokines, such as interleukin 1 (IL-1) and tumor necrosis factor (TNF). These substances have been shown to be involved in an anti-tumor immune response. Malignant tumors in the lungs often cause pleural accumulation of malignant exudate. Therefore, the author tried to understand the cancer cells in the pleural effusion