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目的探讨具有不良孕产史夫妇的不良孕产史与染色体核型异常的关系。方法采用外周血淋巴细胞培养技术,对358例具有不良孕产史的夫妇进行常规G显带核型分析。结果 358例不良孕产史夫妇中,共检出异常染色体核型39例,异常率为10.89%。其中随体变异13例,9号染色体臂间倒位9例,副缢痕的增长8例,相互易位7例,数目异常2例。染色体异常在男女发生的比例相当。结论染色体核型异常是导致不良孕产史的重要原因之一,对不良孕产史夫妇双方进行细胞遗传学检查,提供优生咨询,再孕指导与监测,能够有效防止患儿出生,提高出生人口素质。
Objective To investigate the relationship between the unhealthy history of maternity and the abnormalities of karyotypes in couples with poor history of pregnancy. Methods Peripheral blood lymphocyte culture technique was used to analyze 358 cases with unhealthy pregnancy history. Results Among 358 cases of unhealthy couples, 39 cases of abnormal karyotype were detected, the abnormal rate was 10.89%. Among them, there were 13 cases with variation of body size, 9 cases with inverted arm orientation on chromosome 9, 8 cases with accessory marks, 7 cases with mutual translocation, and 2 cases with abnormal number. Chromosomal abnormalities occur in the same proportion of men and women. Conclusions Chromosome karyotype abnormality is one of the most important causes of adverse pregnancy history. Cytogenetic tests are conducted on both sides of poor pregnancy history and provide prenatal counseling, guidance and monitoring of re-pregnancy, which can effectively prevent the birth of children and increase the birth population Quality.