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目的:分析比较染色体异常与多次自然流产的关系。方法对有两次以上(含两次)自然流产史的346对夫妇进行了外周血染色体核型分析。每个病例观察20个细胞,分析3-5个核型。结果本文346对(692例)两次以上自然流产夫妇中检出78例染色体核型异常及变异者,检出率为11.3%,其中平衡易位占2.5%;检出臂间倒位占1.9%;D与G组染色体多态性占4.2%;1,、9、16号染色体异染色质增多者占1.3%;另外检出Y=G和Y=18号染色体共10例,占1.45%。结论染色体核型异常与反复性自然流产存在着一定的联系,D与G组染色体多态性,1,、9、16号染色体异染色质增多在反复性自然流产人群的检出率颇高,应引起重视。
Objective: To analyze the relationship between chromosomal abnormalities and spontaneous abortion. Methods Peripheral blood karyotypes were analyzed in 346 couples with two or more spontaneous abortions. Twenty cells were observed in each case and 3-5 karyotypes were analyzed. Results Of the 346 pairs (692 cases) of more than twice of spontaneous abortion couples were detected in 78 cases of chromosomal abnormalities and mutations, the detection rate was 11.3%, of which the equilibrium translocation accounted for 2.5%; detection of arm inversion in 1.9 %; D and G chromosome polymorphism accounted for 4.2%; 1, 9, 16 chromosome heterochromatin accounted for 1.3%; other detected Y = G and Y = 18 chromosomes in 10 cases, accounting for 1.45% . Conclusion Chromosome karyotype abnormalities and recurrent spontaneous abortion there is a certain relationship between chromosomes D and G polymorphism, 1, 9, 16 chromosome heterochromatin in recurrent spontaneous abortion crowd detection rate is high, Should pay attention.