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目的 探讨转化生长因子 β(TGF- β)在重症肌无力 (MG)免疫病理机制中的作用。方法 利用体外细胞培养方法和 EL ISA检测技术对 MG患者外周血单个核细胞经乙酰胆碱受体 (Ach R)刺激后产生 TGF- β的水平进行研究。结果 MG患者外周血单个核细胞 TGF- β水平高于正常对照组 ,且 TGF- β水平与病程有关。结论 MG患者自身免疫功能异常 ,TGF-β参与了 MG的免疫病理过程。
Objective To investigate the role of transforming growth factor β (TGF-β) in the pathogenesis of myasthenia gravis (MG). Methods The levels of TGF-β in peripheral blood mononuclear cells stimulated by acetylcholine receptor (Ach R) in MG patients were studied by in vitro cell culture and ELISA detection. Results MG patients with peripheral blood mononuclear cells TGF-β levels higher than the normal control group, and TGF-β levels and duration. Conclusion MG patients with autoimmune dysfunction, TGF-β involved in the immune pathology of MG.