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目的：研究复方丹参注射液在治疗慢性原发性肾小球肾炎中的作用。方法：４５例患者分为２组，常规治疗组１９例（用雷公藤多苷片、潘生丁片、保肾康片治疗）；常规＋丹参组２６例（在常规治疗组用药基础上加复方丹参注射液静脉点滴）。观察治疗前后血浆内皮素（ＥＴ）、降钙素基因相关肽（ＣＧＲＰ）水平。结果：慢性肾炎患者血浆ＥＴ水平高于正常人（Ｐ＜０．０１），而ＣＧＲＰ水平低于正常人（Ｐ＜０．０１），治疗后均显著改善（Ｐ＜０．０１），且以常规治疗＋丹参组改善更为显著，与常规治疗组治疗后比，Ｐ＜０．０１。结论：复方丹参注射液能改善慢性肾炎患者ＥＴ、ＣＧＲＰ的代谢失衡状态。
Objective: To study the effect of compound Danshen injection in the treatment of chronic primary glomerulonephritis. Methods: Forty-five patients were divided into two groups: 19 in the conventional treatment group (treated with Tripterygium Glycosides Tablets, Pansheng Ding Tablets, and Baoshenkang Tablets); 26 in the regular + Salviae Miltiorrhiza group (based on the conventional treatment group plus Compound Salvia Miltiorrhizae Injection intravenously). The plasma endothelin (ET) and calcitonin gene-related peptide (CGRP) levels were observed before and after treatment. Results: Plasma ET levels in patients with chronic nephritis were higher than those in normal subjects (P<0.01), while CGRP levels were lower than those in normal subjects (P<0.01). After treatment, ET levels were significantly improved (P<0.01). The improvement of routine treatment + Salvia miltiorrhiza group was more significant, compared with the conventional treatment group, P<0.01. Conclusion: Compound salvia miltiorrhiza injection can improve the metabolic imbalance of ET and CGRP in patients with chronic nephritis.