The Paleocene collision-related granite porphyries are identified for the first time along the western margin of the Lhunzhub Basin, Tibet. SHRIMP U-Pb zircon analysis indicates that the granite porphyries were emplaced at 58.7±1.1 Ma (MSWD = 0.79) during the Indo-Asian continental collision. The granite porphyries are peraluminous and high in K, belonging to the calc-alkaline to high-K calc-alkaline series. They are relatively enriched in LILE, Th and LREE and depletion in Ba, Nb, P and Ti, characterized by LREE-enriched patterns with slightly to moderately negative Eu anomalies. These Paleocene granite porphyries are interpreted as the products generated by partial melting of the pre-existing arc crustal rocks caused by the increase of pressures and temperatures during the crustal shortening at the early stages of the Indo-Asian continental collision since 65 Ma. Despite inherited geochemical features and tectonic settings of the arc protoliths, they are significantly different from the volcanic rocks of the Dianzhong Formation within the Linzizong Group and the Miocene granite por- phyries in the Gangdise belt. The Paleocene collision-related granite porphyries were identified for the first time along the western margin of the Lhunzhub Basin, Tibet. SHRIMP U-Pb zircon analysis indicates that the granite porphyries were emplaced at 58.7 ± 1.1 Ma (MSWD = 0.79) during the Indo -Asian continental collision. The granite porphyries are peraluminous and high in K, belonging to the calc-alkaline to high-K calc-alkaline series. They are relatively enriched in LILE, Th and LREE and depletion in Ba, Nb, P and Ti , characterized by LREE-enriched patterns with slightly to moderately negative Eu anomalies. These Paleocene granite porphyries are interpreted as the products generated by partial melting of the pre-existing arc crustal rocks caused by the increase of pressures and temperatures during the crustal shortening at the early stages of the Indo-Asian continental collision since 65 Ma. Despite inherited geochemical features and tectonic settings of the arc protoliths, they are significantly different from the volcanic rocks of the Dianzhong Formation within the Linzizong Group and the Miocene granite por- phyries in the Gangdise belt.