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目的:观察VX2兔鼻咽癌生长特点,并与所获病理和MRI结果比较,探讨18F-FDGPET-CT在鼻咽肿物检测中的作用。方法:建立VX2兔鼻咽癌模型后,完成18F-FDGPET-CT和MRI扫描并解剖;在肉眼所见肿瘤周围不同的距离取标本并完整取出斜坡作病理诊断;测量鼻咽肿物最大标准摄取值(SUV),在PET-CT和MRI图像上勾画鼻咽肿物体积。结果:VX2兔鼻咽癌可向周围组织呈广泛浸润性生长;30只兔中经病理确诊有9只兔斜坡受癌细胞侵犯,PET-CT发现6例(66.7%),MRI发现5例(55.6%),CT发现1例(11.1%);兔VX2鼻咽癌的最大SUV值与鼻咽肿物的体积呈负相关,r=-0.426,P=0.03;30只兔在18F-FDGPET-CT图像上所勾画的鼻咽肿物体积较在MRI图像上勾画体积小,差异无统计学意义,P=0.17。结论:18F-FDGPET-CT能对鼻咽癌病灶范围的确定、放疗靶区的准确勾画提供有用的信息。
OBJECTIVE: To observe the growth characteristics of nasopharyngeal carcinoma in VX2 rabbits and to explore the role of 18F-FDG PET-CT in the detection of nasopharyngeal masses compared with the pathological findings and MRI findings. Methods: After establishing the VX2 rabbit nasopharyngeal carcinoma model, 18F-FDG PET-CT and MRI scanning were completed and dissected. The specimens were taken at different distances around the tumor and the complete removal of the slope was made for pathological diagnosis. The maximum standard intake of nasopharyngeal tumor Values (SUVs), depicting nasopharyngeal mass on PET-CT and MRI images. Results: VX2 rabbit nasopharyngeal carcinoma showed extensive invasive growth to the surrounding tissues. Nine rabbits pathologically confirmed by pathology were infested by cancer cells. PET-CT was found in 6 cases (66.7%) and MRI in 5 cases 55.6%, CT was found in 1 case (11.1%); the maximum SUV value of rabbit VX2 nasopharyngeal carcinoma was negatively correlated with the volume of nasopharyngeal tumor (r = -0.426, P = 0.03) The volume of nasopharyngeal tumor sketched on the CT image is smaller than that of the MRI image, the difference was not statistically significant (P = 0.17). Conclusion: 18F-FDG PET-CT can provide useful information for the determination of the extent of lesions in NPC and the accurate delineation of target areas for radiotherapy.