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目的建立生肌玉红膏提取制备工艺优化与质控标准。方法采用高压液相仪测定有效成分含量,通过正交设计优化确定制备工艺参数、条件与流程。结果生肌玉红膏制备工艺为:取当归、甘草二味,混匀,用70%乙醇加热回流提取2次,每次加8倍量乙醇,回流提取1 h,合并滤液回收乙醇至无醇味,备用。另取白芷、紫草二味,混匀,粉碎成粗粉,过20目筛,以8倍量70%乙醇作溶剂,浸渍8小时后进行渗漉提取,渗漉速度为0.5 ml·(min·kg)-1,收集渗漉液,合并,将血竭加入渗漉液中,搅匀,使溶解,再加入当归、甘草提取物,搅匀使溶解。结论生肌玉红膏制备工艺与质控标准稳定可行。
OBJECTIVE To establish the optimization and quality control standards for the preparation of Shengji Yuhong cream. Methods The content of active ingredients was determined by high pressure liquid chromatography and the preparation process parameters, conditions and flow were determined by orthogonal design. Results Myogenic Jade Red Cream preparation process: take angelica, licorice two flavor, mix, with 70% ethanol heated refluxed twice, each time plus 8 times the amount of ethanol, reflux extraction 1 h, the combined filtrate was recovered ethanol to alcohol Taste, spare. Another Angelica, Lithospermum two flavor, mix, crushed into coarse powder, 20 mesh sieve to 8 times the amount of 70% ethanol as solvent, 8 hours after immersion percolation extraction, percolation rate of 0.5 ml · (min · Kg) -1, collected percolation liquid, merged, the blood will be added to the percolation liquid, stir, to dissolve, then add Angelica, licorice extract, stir to dissolve. Conclusion The preparation and quality control standards of Shengji Yuhong Cream are stable and feasible.