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目的探讨乙型肝炎肝纤维化血清学指标与肝穿结果的相关性。方法对于80例乙型肝炎肝穿患者,同时采取静脉血检测血清透明质酸(HA)、血清透明质酸(LN)、III型前胶原(PCIII)、IV型胶原蛋白(IV.C)。结果乙型肝炎肝纤维化患者血清IV-C、LN、HA、PCⅢ水平高于正常对照,HA、LN、IV-C水平按纤维化的轻、中、重程度次序递增(P<0.5)。与病理诊断成正相关(P<0.01)。结论血清IV-C、LN、HA、PCⅢ水平测定可较好反映肝纤维化程度,HA、LN、IV-C与病理诊断成正相关。
Objective To investigate the correlation between hepatitis B perfusion and serological markers of hepatitis B liver fibrosis. Methods Serum hyaluronic acid (HA), serum hyaluronic acid (LN), type III procollagen (PCIII) and type IV collagen (IV.C) were determined in 80 patients with hepatitis B through liver biopsy. Results Serum levels of IV-C, LN, HA and PCⅢ in patients with hepatitis B were higher than those in controls. The levels of HA, LN and IV-C were increased in the order of mild, moderate and severe fibrosis (P <0.5). And pathological diagnosis is positively related (P <0.01). Conclusion Serum levels of IV-C, LN, HA and PCIII can reflect the degree of liver fibrosis. HA, LN and IV-C are positively correlated with pathological diagnosis.