转录因子AP-2α参与哺乳动物的胚胎发育和癌症发生过程,许多研究已经表明它能与很多蛋白质发生相互作用。通过免疫共沉淀(CO-IP)实验发现AP-2α与酪蛋白激酶2的B亚基(CK2β)有相互作用,在后续的内源性免疫共沉淀实验中,又发现酪蛋白激酶2的催化亚基A(CK2α)也存在于CK2β与AP-2α这个复合物当中。结果有助于进一步研究CK2如何通过与AP-2α相互作用来调节AP-2α的转录活性。 The transcription factor AP-2α is involved in mammalian embryonic development and carcinogenesis and many studies have shown that it interacts with many proteins. AP-2αwas found to interact with the B subunit of casein kinase 2 (CK2β) by co-immunoprecipitation (CO-IP). In the subsequent endogenous immunoprecipitation experiments, it was found that the catalytic activity of casein kinase 2 Subunit A (CK2α) is also present in the complex between CK2β and AP-2α. The results will help further study how CK2 regulates AP-2α transcriptional activity by interacting with AP-2α.