血小板增多可以出现在许多疾病过程中。慢性肺疾患、结缔组织病、骨髓增生病以及感染经常伴随血小板计数增加。一个多世纪以前,Riess首次观察到恶性肿瘤与血小板增多之间的关系。最近的研究已证实了这一发现。现在有显微实验证据显示,肿瘤细胞、血小板和内皮细胞之间的相互作用可能引起肿瘤细胞在微血管的寄宿,增加了转移的发生以及导致预后不良。 Thrombocytosis can occur in many diseases. Chronic lung disease, connective tissue disease, myeloproliferative disorders and infections often accompany increased platelet counts. More than a century ago, Riess first observed the relationship between malignancy and thrombocytosis. Recent research has confirmed this finding. There is now microscopic evidence that interactions between tumor cells, platelets and endothelial cells may cause tumor cells to host microvessels, increase the incidence of metastases and lead to poor prognosis.