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作者报告了10名有妊娠糖尿病史(非胰岛素依赖性糖尿病)妇女于产后服用低剂量口服避孕药(OC)后的碳水化合物代谢的变化,并以8名健康妇女作对照。所有对象均系产后6个月以上,年龄为35岁以上,体重、血压正常,在参与研究的3个月内未用激素类药物。OC内含雌二醇30μg和左旋18-甲基炔诺酮150μg,每周期给药3周,停药1周。用药前及服药2、6个月后进行口服葡萄糖耐量试验,并测定血浆葡萄糖及胰岛素、葡萄朊含量,同时记录体重和血压。结果表明用OC前有妊娠糖尿病史的妇女空腹血糖高于对照组,而胰岛素值低于正常,血葡萄朊值二组间无差异,用OC后二组的空腹血糖,胰岛素和葡萄朊值均与用药前无明显变化。口服葡萄糖
The authors reported changes in carbohydrate metabolism in 10 women with a history of gestational diabetes (non-insulin-dependent diabetes mellitus) after taking a low-dose oral contraceptive (OC) postpartum and compared them to 8 healthy women. All subjects were postpartum 6 months or more, aged 35 years or older, weight, normal blood pressure, did not use hormone drugs within 3 months of participating in the study. OC contains estradiol 30μg and levonor 18-norgestrel 150μg, 3 weeks for each cycle, withdrawal for 1 week. Oral glucose tolerance test was performed before medication and 2, 6 months after taking the medicine. Plasma glucose, insulin, and grape protein contents were also measured. Body weight and blood pressure were also recorded. The results showed that women with a history of gestational diabetes before the OC had higher fasting blood glucose levels than those of the control group, while insulin levels were lower than normal. There was no difference between the two groups in the blood glucose level. The fasting blood glucose, insulin and grape protein values No significant change before treatment. Oral glucose