血小板生成素(Tpo),即 c-Mpl 受体配基是巨核细胞造血的主要调节物。用 Tpo 治疗老鼠在几天之内可以使血小板数量增加4倍。c-Mpl 基因敲出的小鼠的血小板数目是正常鼠的15%。c-Mpl 受体的亚基结构尚未完全了解。一些能刺激巨核造血的细胞因子 Thrombopoietin (Tpo), the c-Mpl receptor ligand, is the major regulator of megakaryocyte hematopoiesis. Treating mice with Tpo increased the number of platelets by a factor of four in just a few days. The number of platelets in the c-Mpl knockout mice was 15% of normal mice. The subunit structure of the c-Mpl receptor has not been fully understood. Some cytokines that stimulate megakaryocytes