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目的观察尿激酶冲洗联合局部亚低温治疗高血压性脑出血(HICH)的临床疗效。方法选取2011年6月—2015年3月龙川县人民医院收治HICH患者120例,采用随机数字表法分为对照组和观察组,每组60例。对照组患者给予尿激酶冲洗治疗,观察组患者给予尿激酶冲洗联合局部亚低温治疗。比较两组患者手术前后颅内压、术后1周有效率及术后3个月临床疗效。结果两组患者术前颅内压比较,差异无统计学意义(P>0.05);观察组患者术后1、2、3 d颅内压均低于对照组(P<0.05)。两组患者术后1周有效率比较,差异无统计学意义(P>0.05)。观察组患者术后3个月临床疗效优于对照组(u=3.07,P<0.05)。结论尿激酶冲洗联合局部亚低温治疗HICH的临床疗效较好,能够有效降低患者颅内压,改善患者日常生活能力。
Objective To observe the clinical efficacy of urokinase flushing combined with local mild hypothermia in the treatment of hypertensive intracerebral hemorrhage (HICH). Methods 120 patients with HICH admitted from June 2011 to March 2015 in Longchuan County People’s Hospital were randomly divided into control group and observation group with 60 cases in each group. Patients in the control group were treated with urokinase and patients in the observation group were treated with urokinase combined with local mild hypothermia. The intracranial pressure, the effective rate after 1 week and the clinical effect at 3 months after operation were compared between the two groups. Results There was no significant difference in preoperative intracranial pressure between the two groups (P> 0.05). The intracranial pressure of the observation group was significantly lower than that of the control group at 1, 2 and 3 days (P <0.05). Two groups of patients 1 week after the effective rate comparison, the difference was not statistically significant (P> 0.05). The clinical efficacy of the observation group was better than that of the control group at 3 months (u = 3.07, P <0.05). Conclusion The clinical efficacy of urokinase combined with local mild hypothermia in the treatment of HICH is better, which can effectively reduce intracranial pressure and improve patients’ daily living ability.