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本文利用体外培养方法,比较了47名服药妇女与50名从未服药的对照妇女人工流产胎儿的染色体畸变率,未发现显著性差异;观察了孕期不同服药情况—孕期继续服药、孕前停药与对照组的染色体畸变率,亦未见明显差异。比较了服药与对照组各19名妇女的胎儿细胞的 SCE 值,发现服药组SCE 值明显增高。研究结果提示,长期服用甾体口服避孕药对胎儿染色体可能具有微弱的诱变作用,不宜在停药后短期内受孕,亦不宜孕期继续服药。
In this paper, the method of in vitro culture was used to compare the chromosome aberration rate of abortion fetus among 47 women who took the medicine and 50 women who have never taken the medicine. There was no significant difference between the two groups. Different medication during pregnancy was observed. There was no significant difference in the rate of chromosome aberration in the control group. The SCE values of fetal cells from 19 women in the medication group and the control group were compared, and the SCE value in the medication group was significantly higher. The results suggest that long-term use of steroidal oral contraceptives may have a faint mutagenic effect on fetal chromosomes, should not be short-term after stopping pregnancy, it is not appropriate to continue taking medication during pregnancy.