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目的探讨生存素(Survivin)和环氧化酶-2(cyclooxygenase-2,Cox-2)在T细胞非霍奇金淋巴瘤(T cell non-Hodgkin’s lymphoma,T-NHL)中的表达及临床意义。方法对2000年1月至2006年12月中南大学湘雅医院和中南大学湘雅二医院57例T-NHL和10例良性淋巴结病变采用免疫组化SP法检测组织中Survivin和Cox-2的表达,并与相应的临床参数进行对比分析。结果Survivin和Cox-2在T-NHL中的阳性表达率分别为78.9%和57.9%,与对照组比较差异有统计学意义(P<0.05)。Survivin的表达与Cox-2的表达呈正相关(P<0.01)。Sur-vivin和(或)Cox-2阳性组5年存活率均分别低于Survivin和(或)Cox-2阴性组,差异有统计学意义(P<0.05)。多因素分析显示,Survivin和Cox-2均是T-NHL的独立预后因素。结论Survivin和Cox-2在T-NHL中表达上调以及两者之间表达呈正相关,提示Survivin和Cox-2的表达与T-NHL的发生发展有关,且提示预后不良。
Objective To investigate the expression and clinical significance of Survivin and cyclooxygenase-2 (Cox-2) in T cell non-Hodgkin’s lymphoma (T-NHL) . Methods From January 2000 to December 2006, 57 cases of T-NHL and 10 cases of benign lymphadenopathy in Xiangya Hospital of Central South University and Xiangya Second Central Hospital were enrolled. The expressions of Survivin and Cox-2 were detected by immunohistochemical SP method , And compared with the corresponding clinical parameters. Results The positive rates of Survivin and Cox-2 in T-NHL were 78.9% and 57.9%, respectively, which were significantly different from those in control group (P <0.05). Survivin expression was positively correlated with Cox-2 expression (P <0.01). The 5-year survival rates of Survivin and / or Cox-2 positive group were lower than those of Survivin and / or Cox-2 negative group, respectively (P <0.05). Multivariate analysis showed that both Survivin and Cox-2 were independent prognostic factors of T-NHL. Conclusions Up-regulation of Survivin and Cox-2 in T-NHL and positive correlation between the expression of Survivin and Cox-2 suggest that the expression of Survivin and Cox-2 are related to the occurrence and development of T-NHL.