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目的探讨血清C-肽水平测定在Ⅱ型糖尿病诊疗中的临床意义。方法将65例Ⅱ型糖尿病患者为病例组,42例健康受试者为正常对照组,两组均禁食12h。次晨对两组对象在空腹及进食标准馒头餐后1、2、3h采血以化学发光法测定血清C-肽水平和胰岛素。结果Ⅱ型糖尿病组空腹C肽测定值较正常对照组高,C肽于2h达高峰,释放峰值延迟,3h仍不能恢复至正常水平,餐后C肽是空腹C肽的3倍;正常对照组C肽于1h达峰值,3h降至空腹水平,餐后C肽是空腹C肽的6倍。结论血清C肽水平更能全面准确反映胰岛β细胞的分泌功能,对Ⅱ型糖尿病的诊疗具有重要指导意义。
Objective To investigate the clinical significance of serum C-peptide in the diagnosis and treatment of type Ⅱ diabetes mellitus. Methods Sixty-five patients with type 2 diabetes mellitus were selected as the case group and 42 healthy subjects as the normal control group. Both groups were fasted for 12 hours. The next morning two groups of subjects in the fasting and eating standard steamed bread 1,2,3 h after meal blood chemiluminescence method for the determination of serum C-peptide levels and insulin. Results The fasting C-peptide level in type 2 diabetes mellitus group was higher than that in normal control group. The C peptide peaked at 2h, peak delay was delayed and returned to normal level after 3h. The postprandial C peptide was 3 times higher than the fasting C- C peptide peaked at 1h, 3h reduced to fasting levels, postprandial C-peptide is 6-fold fasting C-peptide. Conclusions Serum C-peptide level can reflect the secretion function of pancreatic islet cells more accurately and completely, which is of great guiding significance for the diagnosis and treatment of type II diabetes.