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目的探讨2型糖尿病合并冠心病的患者胰岛素抵抗程度及IL-6、TNF-α的水平变化在糖尿病冠心病发生、发展中的作用。方法比较60例2型糖尿病并发冠心病患者与60例糖尿病无并发症患者以及60例健康者的生化指标和放免法测定的血清IL-6、TNF-α、Homa-IR指数的差异性。结果 2型糖尿病并发冠心病组与无并发症组IL-6、TNF-a和Homa-IR水平比较均显著升高(P<0.01)。且IL-6与Homa-IR、IL-6与TNF-α、Homa-IR与TNF-α成正相关。结论 IL-6、TNF-α等炎症标志物的高表达促进了糖尿病冠心病的发生及发展,且与胰岛素抵抗程度呈正相关;检测糖尿病患者血清IL-6、TNF-α、Homa-IR的水平有利于监测其病情、评价疗效及预防并发症,具有重要的临床意义。
Objective To investigate the changes of insulin resistance and the levels of IL-6 and TNF-α in patients with type 2 diabetes mellitus complicated with coronary heart disease and their significance in the pathogenesis and progression of coronary heart disease. Methods The difference of serum IL-6, TNF-α, Homa-IR index between 60 patients with type 2 diabetes mellitus complicated with coronary heart disease and 60 patients without diabetes mellitus and 60 healthy controls were compared by biochemical methods and radioimmunoassay. Results The levels of IL-6, TNF-a and Homa-IR in type 2 diabetic patients with coronary heart disease were significantly higher than those without complications (P <0.01). IL-6 was positively correlated with Homa-IR, IL-6 and TNF-α, Homa-IR and TNF-α. Conclusion The high expression of IL-6, TNF-α and other inflammatory markers promote the occurrence and development of diabetic coronary heart disease, which is positively correlated with the degree of insulin resistance. The levels of serum IL-6, TNF-α and Homa-IR in diabetic patients Is conducive to monitoring its condition, evaluate the efficacy and prevent complications, has important clinical significance.