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目的测定肿瘤患者围术期红细包免疫功能的变化。方法随机选取在本院行肿瘤切除术的患者40例作为实验组。ASA分级1-3级。门诊体检的正常人群作为对照组。其中良性肿瘤16例。恶性肿瘤24例。其诊断标准均符和肿瘤诊断标准。其中乳癌10例。其中直肠癌6例。甲状腺癌2例,胃癌6例,甲状腺囊肿8例,乳腺良性包块8例。分别测定其术前,术中,术后三种血样,肝素抗凝后送检。采用郭峰设计的酵母菌花环试验法测定红细胞的免疫功能。结果无论良恶性肿瘤患者与正常人相比其在不同时期的红细胞RBC-C3bRR均降低;其中乳房良性包块(P>0.05);甲状腺囊肿(P>0.05);胃癌早期(P<0.05);其余各组差别显著(P<0.01);而肿瘤患者RBC-ICR升高,其中良性肿瘤(P>0.05),甲癌(P<0.05),其他组(P<0.01)。结论肿瘤患者红细胞免疫功能受到不同程度的抑制,其中晚期恶性着,红细胞免疫功能最低,预后不良。手术切除后因解除了肿瘤的刺激和压迫,红细胞免疫功能得到不同程度的恢复。
Objective To determine the changes of immune function in perioperative red sachet in patients with cancer. Methods Totally 40 patients undergoing tumor resection in our hospital were randomly selected as the experimental group. ASA level 1-3. Outpatient physical examination of the normal population as a control group. Of which 16 cases of benign tumors. 24 cases of malignant tumor. The diagnostic criteria and tumor diagnostic criteria. Including 10 cases of breast cancer. Including 6 cases of rectal cancer. 2 cases of thyroid cancer, 6 cases of gastric cancer, thyroid cyst in 8 cases, 8 cases of benign breast mass. Respectively measured preoperative, intraoperative and postoperative three blood samples, heparin anticoagulation after submission. The immune function of erythrocytes was determined by the yeast wreath test designed by Guo. Results Compared with normal controls, the RBC-C3bRR of erythrocytes in benign and malignant tumors were significantly lower than those in normal controls (P> 0.05), thyroid cyst (P> 0.05), early gastric cancer (P <0.05) (P <0.01). The RBC-ICR of tumor patients increased, including benign tumor (P> 0.05), A carcinoma (P <0.05) and other groups (P <0.01). Conclusion The erythrocyte immune function of tumor patients is inhibited to varying degrees, of which the late malignant, the lowest immune function of red blood cells, poor prognosis. After surgical resection due to the lifting of the tumor stimulation and oppression, red blood cell immune function were restored to varying degrees.