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目的为评价关木通生品及其制品是否具有利尿作用和其安全性,对二者进行药效学、急性毒性和长期毒性的比较研究。方法采用正常大鼠水负荷的动物模型,观察关木通生品、制品水煎剂的一次性给药和连续3d(1次/d)给药的利尿作用。结果关木通生品、制品水煎剂均无明显的利尿作用。关木通生品水煎剂的LD50为50.32g/kg,关木通制品的LD50为226.62g/kg,且该药急性毒性小鼠的死亡时间主要分布于药后48～72h之间。经过本研究初步拟定的炮制工艺炮制后的关木通制品,对肾脏的毒性明显低于同等剂量的关木通生品。结论关木通生品及其制品均没有利尿作用,炮制可以达到减毒的目的。
Objective To evaluate whether GuanMuTong products and their products have diuretic effect and their safety, and compare the pharmacodynamics, acute toxicity and long-term toxicity of the two. Methods The animal model of normal rat water load was used to observe the one-time administration of Guan Mu Tong Sheng products and product water decoction and the diuretic effect of consecutive 3 days (1 time/d) administration. [Results] There was no obvious diuretic effect of Guan Mu Tong Health Products and products water decoction. The LD50 of Guan Mu Tong Shui Decoction was 50.32 g/kg, the LD50 of Guan Mu Tong was 226.62 g/kg, and the death time of acute toxicity mice was mainly distributed between 48 and 72 hours after the drug. After the preliminary formulation of the research process, the Guanmu-based products processed by the processing technology were significantly less toxic to the kidney than the equivalent dose of Guanmu Tongsheng. Conclusion Guanmu Tongpin and its products have no diuretic effect, and the processing can achieve the purpose of attenuating.