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目的探索屈光不正性弱视儿童枕叶面积改变及其规律。设计非随机化的临床试验。研究对象10例屈光不正性弱视儿童及10例视力正常的儿童。方法以1.5T磁共振对10例屈光不正性弱视患儿及10例视力正常儿童进行全脑扫描,应用三维磁化准备快速梯度回波(MPRAGE)序列采集三维解剖数据,采用FreeSurfer软件进行处理分析。观察弱视患儿双侧半球枕叶面积有无改变。主要指标双侧半球枕叶的楔叶、舌回、枕外侧叶和距状沟周边区四个部分的面积。结果两组被试的年龄没有统计学差异。屈光不正性弱视患儿双侧半球楔叶、舌回和距状沟周边区,左侧半球枕外侧叶与对照组相比范围明显变小(P均<0.05);右侧半球枕外侧叶没有发生显著性改变(P>0.05)。结论MRI技术可以无创性评估皮层形态结构改变,该技术在临床随访研究及治疗评估上具有潜在的应用价值。屈光不正性弱视患者相关视觉皮层面积发生了改变,提示皮层形态及功能改变与弱视发生、发展密切相关。(眼科,2007,16:315-318)
Objective To explore the change of occipital lobe area and its regularity in children with refractive amblyopia. Design non-randomized clinical trials. The study included 10 children with ametropia amblyopia and 10 children with normal vision. Methods Whole brain scanning was performed on 10 children with ametropia amblyopia and 10 normal children with normal vision by 1.5T magnetic resonance. Three-dimensional anatomical data were acquired by three-dimensional magnetization preparation MPRAGE sequence and processed by FreeSurfer software . Observed amblyopia in children with bilateral hemispheric occipital lobe area without change. The main indicators of bilateral hemispheric occipital lobe wedge, tongue back, lateral occipital lobe and distance ditch surrounding the four parts of the area. Results There was no significant difference in age between the two groups. The areas of the bilateral hemispheric wedge leaves, lingual gyrus and ditch-shaped ditch peripheral area in the children with amblyopia amblyopia were significantly smaller than those in the control group (all P <0.05) No significant change (P> 0.05). Conclusion MRI can assess the changes of cortical structures noninvasively. This technique has potential value in clinical follow-up and therapeutic evaluation. Refractive amblyopia in patients with visual cortex area has changed, suggesting that changes in cortical morphology and function and amblyopia are closely related to the development. (Ophthalmology, 2007, 16: 315-318)