目的探讨宫颈环形电切术(LEEP)联合保妇康栓治疗宫颈上皮内瘤变(CIN)的临床疗效。方法将某院收治的CIN患者174例随机分为单纯手术组和联合治疗组,每组各67例。单纯手术组行LEEP术,联合治疗组在术后次月月经干净后使用保妇康栓,连用6d。将两组切下组织行病理检查,并与术前阴道镜病理检查的结果比较。观察术后阴道排液时间、创面愈合情况及并发症发生情况。结果 LEEP术后病理结果与阴道活检结果的符合率为77.6%。联合治疗组的阴道排液时间、创面愈合时间均显著低于单纯手术组,差异有统计学意义(P﹤0.05)。联合治疗组术后创面感染、宫颈管狭窄及宫颈管粘连等并发症的发生率均显著低于单纯手术组,差异有统计学意义(P﹤0.05)。结论 LEEP联合保妇康栓是治疗CIN一种安全有效的方法,可减少术后排液及术后并发症。 Objective To investigate the clinical effect of cervical ring electrosurgery (LEEP) combined with Baofukang suppository in the treatment of cervical intraepithelial neoplasia (CIN). Methods A total of 174 patients with CIN admitted to a hospital were randomly divided into simple operation group and combined treatment group, with 67 cases in each group. Simple operation group LEEP surgery, combined treatment group after menstruation the next month after the use of Baofukang suppository, once every 6d. The two groups of patients underwent histopathological examination and compared with the results of preoperative colposcopy pathological examination. Vaginal drainage time, wound healing and complications were observed. Results The coincidence rate of LEEP postoperative pathological results and vaginal biopsy results was 77.6%. Vaginal drainage time and wound healing time in the combined treatment group were significantly lower than those in the simple operation group, the difference was statistically significant (P <0.05). The incidence of postoperative wound infection, cervical stenosis and cervical canal adhesion in the combination therapy group was significantly lower than that in the simple surgery group (P <0.05). Conclusions LEEP combined with Baofukang suppository is a safe and effective method to treat CIN, which can reduce postoperative drainage and postoperative complications.