：本文采用实验室常见且价廉的丙酮、甲醛、乙酸酐、叔丁醇及异氯丙烷为原料，通过醛酮缩会、酸酐酰化、格氏反应等方法，合成了甲瓦龙酸内酯，收率达到35％-45％。经元素分析、红外分析及折光率测定，表明最终产物确是甲瓦龙酸内酯。 : In this paper, common laboratory and inexpensive acetone, formaldehyde, acetic anhydride, tert-butanol and isopropanol as raw materials, aldehydes and ketones by condensation, anhydride acylation, Grignard reaction and other methods to synthesize mevalon acid Ester yield of 35% -45%. The elemental analysis, infrared analysis and refractive index determination, the final product is indeed mevalonolactone.