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应用放射配体结合测定法、放射免疫测定法测定１１０例乙型病毒性肝炎（乙肝）患者外周血淋巴细胞糖皮质激素受体（ＧＲ）与血浆皮质醇（Ｆ）的变化。其中急性重症肝炎２０例、慢性重症肝炎２０例，慢性迁延性肝炎２０例，慢性活动性肝炎５０例以及对照组４０例。结果表明：各类乙肝患者ＧＲ水平明显低于对照组，而血浆Ｆ高于对照组。同时测定２０例慢性活动性肝炎稳定期ＧＲ、Ｆ的变化，发现随病情的改善ＧＲ水平也升高，而血浆Ｆ无明显改变。
Radioligand binding assay and radioimmunoassay were used to determine the changes of glucocorticoid receptor (GR) and plasma cortisol (F) in peripheral blood lymphocytes of 110 patients with viral hepatitis B (B). Including 20 cases of acute severe hepatitis, 20 cases of chronic severe hepatitis, 20 cases of chronic persistent hepatitis, 50 cases of chronic active hepatitis and 40 cases of control group. The results showed that: GR levels in various types of hepatitis B patients were significantly lower than those in the control group, while plasma F was higher in the control group. At the same time, the changes of GR and F in 20 patients with chronic active hepatitis were determined at the same time. It was found that the level of GR increased with the improvement of the disease, while the plasma F had no obvious change.