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对10茶犬作胃一空肠吻合术,建立胆汁返流性胃炎实验模型。可见该模型胃液中胆酸明显高于术前(P<0.01),同时游离酸和Na+均有不同程度升高,pH值降低;胃粘膜表现糜烂、溃疡、炎细胞浸润。作者认为在胆汁返流性胃炎的发病中,胆酸对胃粘膜的破坏起着主要作用,且返流时间与病变程度成正比。结合58例舰员病例观察研究,结果与动物模型相符,从而证实了本文对胆汁返流性胃炎发病机理的基本论点。
Gastro-jejunal anastomosis was performed on 10 dogs, and experimental model of bile reflux gastritis was established. Seen in this model gastric juice was significantly higher than the preoperative cholic acid (P <0.01), while both free acid and Na + increased to varying degrees, pH decreased; gastric mucosa showed erosion, ulcers, inflammatory cell infiltration. The authors believe that in the pathogenesis of bile reflux gastritis, bile acid plays a major role in the destruction of gastric mucosa, and reflux time is proportional to the degree of disease. Combined with the observation and study of 58 crew members, the results are consistent with the animal model, thus confirming the basic argument of the pathogenesis of bile reflux gastritis.