以手性N ,N 二甲基二茂铁乙胺为原料,采用文献报道的方法合成了两个具有平面手性的二茂铁N ,O 配体,并将其应用到苯乙炔对醛的不对称加成反应之中,考察了不同溶剂和不同底物的影响.结果表明,配体(R) 1 [(α二甲胺基)乙基] (S) 2 (二苯基羟基甲基)二茂铁催化剂对该类反应具有较高的催化活性及较好的手性诱导能力,乙醚是该体系最好的溶剂,苯甲醛为底物时可获得高达82 %的对映选择性 Two chiral ferrocene N, O ligands were synthesized from chiral N, N-dimethyl-ferroceneethylamine using literature methods and applied to the conversion of phenylacetylene to aldehydes Among the asymmetric addition reactions, the effects of different solvents and different substrates were investigated. The results showed that the ligand (R) 1 [(α dimethylamino) ethyl] (S) 2 (diphenylhydroxymethyl ) Ferrocene catalyst has high catalytic activity and good chiral induction ability for this kind of reaction. Ether is the best solvent for this system. When benzaldehyde is a substrate, up to 82% enantioselectivity