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近来,作者描述了一种敏感的固相放射免疫试验检测抗心脂抗体,在大量的系统性红斑狼疮和有关的自身免疫性疾病的随访研究中,作者发现在血小板减少症和升高的抗心脂抗体水平间有一个强的统计学相关性.并且报告了慢性自身免疫性血小板减少性紫癜(AITP)病人的抗心脂抗体水平升高,根据研究指出了这些抗体与几种磷脂有交叉反应,还提出这些抗体能结合到血小板膜的磷脂上,使网状内皮系统增加对血小板的破坏.
Recently, the authors described a sensitive solid-phase radioimmunoassay for the detection of anti-lipid antibodies. In a large follow-up study of systemic lupus erythematosus and related autoimmune diseases, the authors found that in thrombocytopenia and elevated anti- There was a strong statistical correlation between the levels of cardiolipin antibodies and an increased level of anti-lipid antibodies was reported in patients with chronic autoimmune thrombocytopenic purpura (AITP), according to the study indicating that these antibodies cross with several phospholipids Reaction, it is also proposed that these antibodies bind to the phospholipids on the platelet membrane, allowing the reticuloendothelial system to increase platelet destruction.