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目的测定冠心病不稳定型心绞痛和稳定型心绞痛外周静脉血中白细胞介素18的浓度,观察其与心绞痛的临床相关性。方法选择不稳定型心绞痛患者40例、稳定型心绞痛患者20例和对照组20例,均进行冠状动脉造影和超声心动图检查,采用酶联免疫吸附法测定外周血清白细胞介素18浓度。结果与对照组比较,心绞痛组患者白细胞介素18浓度明显增高,冠心病左心室射血分数≤50%组患者的白细胞介素18浓度显著高于左心室射血分数>50%组的心绞痛患者,但不稳定型心绞痛组与稳定型心绞痛组之间白细胞介素18浓度差异无统计学意义。结论白细胞介素18浓度随冠状动脉病变的发生和心功能降低而升高,但与动脉粥样硬化斑块的稳定性无关。白细胞介素18的浓度可能对冠心病心绞痛患者的诊断及预后有重要参考价值。
Objective To determine the concentration of interleukin 18 in peripheral venous blood of patients with unstable angina pectoris and stable angina pectoris and observe its clinical relevance with angina pectoris. Methods Forty cases of unstable angina pectoris, 20 cases of stable angina pectoris and 20 cases of control group were enrolled in this study. Coronary angiography and echocardiography were performed. Serum IL - 18 levels were measured by enzyme - linked immunosorbent assay. Results Compared with the control group, the concentration of interleukin-18 in patients with angina pectoris was significantly higher than that of patients without angina pectoris, and the levels of interleukin-18 in patients with coronary artery disease with left ventricular ejection fraction ≤50% were significantly higher than those in patients with left ventricular ejection fraction> 50% , But there was no significant difference in the concentration of interleukin 18 between unstable angina pectoris group and stable angina pectoris group. Conclusion Interleukin-18 concentration increases with the occurrence of coronary artery lesion and cardiac function, but not with the stability of atherosclerotic plaque. The concentration of interleukin 18 may have important reference value for the diagnosis and prognosis of patients with coronary heart disease and angina pectoris.