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不安腿综合征(Restless Legs Syndrome,RLS)多发生于中年人,安静时出现症状,活动后则减轻,患者无法静坐。主要特征是小腿部不适,下肢疼痛无力,牵拉感、刺痛感和蚁行感,有时甚至引起肌阵挛。常规治疗方法是使用镇静、镇痛和扩血管等药物。据近年文献报道,该症的治疗取得了新进展,简述如下,供临床参考。 1 藻酸双酯钠(Polysaccharide Sulfate,PSS) 吴铁军等用PSS治疗RLS患者21例。用法:100mg,tid po,15d为1疗程。结果:治疗1个疗程后全部有效,未发现不良反应。机制:可能与PSS具有抗凝、降低血液粘稠度及改善微循环有关。 2 氟桂嗪(Flunarizine,FNZ) FNZ又名西比灵,汤正才等用FNZ治疗RLS患者36例,用法:每晚10mg,15d为1疗程,并与同期内
Restless Legs Syndrome (RLS) occurs mostly in middle-aged people, when symptoms appear in the quiet, reduce after the activity, the patient can not sit still. Main features are calf discomfort, weakness in lower extremity, pulling sensation, tingling and ants feeling, and sometimes even cause myoclonus. The usual treatment is the use of sedation, pain and vasodilators and other drugs. According to recent reports in the literature, the disease has made new progress in the treatment, summarized as follows, for clinical reference. 1 Polysaccharide Sulfate (PSS) Wu Tiejun and other PSS treatment of RLS in 21 patients. Usage: 100mg, tid po, 15d for a course of treatment. Results: All treatments were effective after one course of treatment, and no adverse reactions were found. Mechanism: PSS may have anticoagulation, reduce blood viscosity and improve microcirculation. 2 Flunarizine (FNZ) FNZ, also known as Xibing Ling, Tang Zheng only FNZ treatment of 36 patients with RLS, usage: 10mg per night, 15d for a course of treatment, and with the same period