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目的:观察醒脑静注射液联合尤瑞克林治疗2型糖尿病合并急性脑梗死临床疗效及其对血清炎症因子及纤维蛋白原浓度的影响。方法:将2型糖尿病合并急性脑梗死患者130例,随机分为对照组和治疗组。对照组进行常规治疗;治疗组在对照治疗基础上加用醒脑静注射液和尤瑞克林。采用美国国立卫生研究院脑卒中量表(NIHSS)评分和改良Rankin Sacle(MRS)评分法评价神经功能的恢复情况;采用日常生活能力量表(ADL)积分方法评定日常生活能力,炎症因子同型半胱氨酸(Hcy)和超敏C-反应蛋白(hs-CRP)水平及纤维蛋白原(FIB)浓度。结果:总有效率治疗组90.77%,对照组72.31%,2组比较,差异有统计学意义(P<0.05)。治疗组和对照组治疗后的神经功能缺损情况及生活活动能力均得到显著改善,与本组治疗前比较,差异有统计学意义(P<0.05);治疗组治疗后NIHSS、MRS及ADL评分改善更明显,与对照组治疗后比较,差异有统计学意义(P<0.05)。治疗组和对照组治疗后血清中炎症因子Hcy、hs-CRP浓度及FIB含量均显著降低,与本组治疗前比较,差异有统计学意义(P<0.05);治疗组治疗后Hcy、hs-CRP浓度及FIB含量下降更显著,与对照组治疗后比较,差异有统计学意义(P<0.05)。结论:醒脑静注射液联合尤瑞克林治疗2型糖尿病合并急性脑梗死临床效果显著,可改善患者神经功能,可能与抑制炎性因子表达及降低纤维蛋白原浓度有关。
Objective: To observe the clinical effects of xingnaojing injection combined with uracil on type 2 diabetes mellitus complicated with acute cerebral infarction and its effect on serum inflammatory factors and fibrinogen concentration. Methods: 130 type 2 diabetic patients with acute cerebral infarction were randomly divided into control group and treatment group. Control group for conventional treatment; treatment group based on the control plus Xingnaojing injection and uricocain. The NIHSS and Rankin Sacle (MRS) scores were used to evaluate the recovery of neurological function. The daily living ability (ADL) score was used to assess the daily living ability, Cystine (Hcy) and high-sensitivity C-reactive protein (hs-CRP) levels and fibrinogen (FIB) concentrations. Results: The total effective rate was 90.77% in the treatment group and 72.31% in the control group. There was significant difference between the two groups (P <0.05). The treatment group and the control group had significant improvement in the neurological deficits and activities of living after treatment, which were significantly different from those before treatment (P <0.05). The scores of NIHSS, MRS and ADL in the treatment group were improved More significantly, compared with the control group after treatment, the difference was statistically significant (P <0.05). The levels of Hcy, hs-CRP and FIB in the treatment group and control group after treatment were significantly lower than those before treatment (P <0.05). The levels of Hcy, hs- CRP concentration and FIB content decreased more significantly, compared with the control group after treatment, the difference was statistically significant (P <0.05). Conclusion: Xingnaojing injection combined with norepinephrine in the treatment of type 2 diabetes mellitus complicated with acute cerebral infarction has significant clinical effect, which can improve the neurological function, which may be related to inhibiting the expression of inflammatory cytokines and decreasing the fibrinogen concentration.